LL-37
In a trial on leg ulcers, it showed no overall benefit.
Grade B: Some human proof
Small, early or mixed results in people.
The grade is for the use people talk about, not for every use. Filed under: Repair.
How it works
A germ-fighting peptide the body makes in skin and immune cells. It also signals for wound repair.
How it was given in studies
On the skin, on leg ulcers, in a trial of 148 patients.
This is what the studies did. It is not a how-to. Source: Leg ulcer trial. Wound Repair and Regeneration, 2021.
What studies saw
A trial in 148 people with hard-to-heal leg ulcers put it on the wound alongside compression. Overall, healing was no better than placebo. A look-back at people with large ulcers hinted at a benefit, which needs its own trial.
The trade-off
FDA says it lacks safety information, and that lab research points to possible harm to male fertility and possible tumor growth in some tissues.
When it showed up, in studies
The trial found no overall benefit.
Sources
Put this grade on your site
Copy the line below. The badge links back to this page, so readers can check the sources. It grades the compound in studies. It does not rate any product or seller.
<a href="https://www.workedinrats.com/compounds/ll-37"><img src="https://www.workedinrats.com/badge/ll-37.svg" alt="LL-37: grade B, some human proof. Worked in Rats" width="300" height="72"></a>
Keep going
We show what studies found. We never tell you what to take. Doses vary by study. Check the sources and talk to a doctor.