Every compound
72 compounds, one page each: the grade, what studies saw, the trade-off and the sources.
How to read the stamps
A is strong human proof. B is some human proof. C is animals and lab only. D is forum talk. The grade is for the use people talk about, not for every use.
Repair
BPC-157
Strong in rats. Three tiny human studies, none with a comparison group.
TB-500
Human trials used a different form, for eyes and skin.
GHK-Cu
Human data is on skin creams only.
Collagen + vitamin C
Small human trials, alongside rehab exercise.
LL-37
In a trial on leg ulcers, it showed no overall benefit.
Growth hormone boosters
Ipamorelin
Raises growth hormone in people. No trial shows it builds muscle.
CJC-1295
Small human studies showed higher growth hormone for days.
MK-677
A pill, not a peptide. Raised appetite and blood sugar in trials.
Tesamorelin
FDA-approved, for one specific condition.
Sermorelin
A former prescription drug for children. The adult evidence is tiny.
GHRP-2 and GHRP-6
They release growth hormone and make you hungry. No muscle trial.
Fat loss (GLP-1 family)
Semaglutide
FDA-approved. Prescription only.
Tirzepatide
FDA-approved. Prescription only.
Retatrutide
About 25% weight loss in a final-stage trial. Not approved as of fall 2026.
CagriSema (cagrilintide + semaglutide)
About 20% weight loss in a large trial. Not FDA-approved.
Orforglipron (Foundayo)
The GLP-1 pill. FDA-approved in April 2026.
Survodutide and mazdutide
Two-switch shots: GLP-1 plus glucagon. Big trials, not FDA-approved.
Brain support, over the counter
Alpha-GPC
Small trials. One large study raised a stroke question.
Choline
An essential nutrient. Extra has not been shown to sharpen thinking.
PS + Bacopa
Bacopa has small attention trials. PS trials disagree.
Lion's mane
A few small human trials. Mostly lab work.
L-theanine
Studied with caffeine. A mild effect within the hour.
Saffron
Dozens of small mood trials. People felt better. Clinician ratings did not move.
Magnesium L-threonate
A few small trials, the first run by the maker.
Health and wellness, over the counter
NAD+
Trials used its precursors. Little benefit shown so far.
NAC
An approved hospital drug. Mixed results as a supplement.
TUDCA
One small insulin trial. A big ALS trial missed.
CoQ10
Best result is in heart failure.
5-MTHF + B12
Fixes a shortfall. Little proof beyond that.
Vitamin D3 + K2
Fixes low vitamin D. Big trials found little else.
Omega-3 fish oil
Lowers triglycerides. Heart trials are mixed.
Gym supplements
Creatine
Strong proof, alongside lifting.
Beta-alanine
A small, consistent boost in hard efforts of 30 seconds to 10 minutes.
Citrulline
A few extra reps. No endurance benefit.
HMB
Nothing for trained lifters. A small gain in older adults.
Taurine
A small endurance effect. The longevity claim is animals only.
Testosterone boosters, over the counter
Tongkat ali
Raised testosterone in 5 small trials.
Fadogia agrestis
Rats only, with signs of harm.
Ecdysterone and turkesterone
Trials disagree. Many products contain almost none.
Zinc
Fixes a shortfall. Did not raise testosterone in well-fed men.
Boron
One 8-man study says yes. The only placebo trial says no.
Sleep and stress
Melatonin
Proven, and small. About 7 minutes.
Ashwagandha
Small trials. Rare liver injury on record.
Glycine
Three small trials. One had 7 men.
DSIP
Tiny trials from the 1980s and 1990s. They disagree.
Magnesium glycinate
One trial. A small effect.
Chamomile
Rated sleep a little better. No extra sleep.
Longevity
Epitalon
Lab dish and one research group. No sleep or lifespan trial.
MOTS-c
Mice only. No published human results.
Urolithin A
Two trials. Side results up, main results flat.
Thymosin alpha-1
A hepatitis drug abroad. Not approved in the US.
Rapamycin
Longer-lived mice. A one-year human trial missed its main goal.
Metformin
A diabetes drug. No finished aging trial.
SS-31 (elamipretide)
Approved in 2025 for one rare disease. Failed its larger trial.
SARMs (not approved)
Ostarine
Lean mass up in trials. Not approved.
Ligandrol (LGD-4033)
One 21-day trial. Testosterone fell.
RAD-140
No human muscle trial. Liver injury on record.
Cardarine (GW501516)
Not a SARM. Dropped by its maker.
Fat loss and metabolism, other
AOD-9604
Tested for obesity. Dropped in 2007. Results never published.
5-amino-1MQ
Mice and cells only.
Berberine
Small drops in cholesterol and blood sugar. Mostly short trials from China.
Skin and hair
Glutathione
Small skin trials. Drips made people sick in 2026.
Melanotan II
Darkened skin in 2 of 3 men in one tiny study. Never approved.
Gut health
Psyllium (soluble fiber)
Helped about 1 extra person in 7 with IBS.
Peppermint oil
Beat placebo for IBS symptoms, with more side effects.
Probiotics
Some strains help. Which one matters.
Glutamine
One striking IBS trial. Pooled data show no clear change.
Zinc carnosine
Tiny studies on gut leakiness. No stomach-lining trial.
Digestive enzymes
Less bloating after one very fatty meal, in 18 people.
KPV
Calmed gut inflammation in mice. No human study.
Libido and sex hormones
PT-141 (bremelanotide)
FDA-approved for low desire in premenopausal women. A small effect, lots of nausea.
Kisspeptin
Switches on sex hormones within minutes. Single-session studies only.
We show what studies found. We never tell you what to take.