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The shelf

rat chow, with the grade on the label.

39 over-the-counter supplements. Each one has its grade and a plain store search. Read the grade first.

How this shelf works

  • Nobody pays us. Every link is a plain Amazon search. No affiliate tag. No cut. No sponsor.
  • A link is not a recommendation. Plenty of what sells well has thin proof. The stamp tells you which.
  • Nobody checks the bottle first. The FDA does not approve supplements before they go on sale. FDA page
  • Look for a seal. The USP Verified mark means an independent group tested that the bottle holds what the label says. USP page
  • Not on this shelf: peptides, SARMs and prescription drugs. We don't link to anyone who sells those. See Vendor watch for why.

Repair

B

Brain support

B

Alpha-GPC

Small trials. One large study raised a stroke question.

Search Amazon for alpha gpc →

B

Choline

An essential nutrient. Extra has not been shown to sharpen thinking.

Search Amazon for choline supplement →

B

PS + Bacopa

Bacopa has small attention trials. PS trials disagree.

Search Amazon for phosphatidylserine bacopa →

B

Lion's mane

A few small human trials. Mostly lab work.

Search Amazon for lions mane supplement →

B

L-theanine

Studied with caffeine. A mild effect within the hour.

Search Amazon for l-theanine →

B

Saffron

Dozens of small mood trials. People felt better. Clinician ratings did not move.

Search Amazon for saffron supplement →

B

Magnesium L-threonate

A few small trials, the first run by the maker.

Search Amazon for magnesium l-threonate →

Health and wellness

B

NAD+

Trials used its precursors. Little benefit shown so far.

Search Amazon for nad supplement →

B

NAC

An approved hospital drug. Mixed results as a supplement.

Search Amazon for nac n-acetyl cysteine →

B

TUDCA

One small insulin trial. A big ALS trial missed.

Search Amazon for tudca →

B

CoQ10

Best result is in heart failure.

Search Amazon for coq10 →

B

5-MTHF + B12

Fixes a shortfall. Little proof beyond that.

Search Amazon for methylfolate b12 →

B

Vitamin D3 + K2

Fixes low vitamin D. Big trials found little else.

Search Amazon for vitamin d3 k2 →

B

Omega-3 fish oil

Lowers triglycerides. Heart trials are mixed.

Search Amazon for omega-3 fish oil →

Gym supplements

A

Beta-alanine

A small, consistent boost in hard efforts of 30 seconds to 10 minutes.

Search Amazon for beta-alanine →

B

Citrulline

A few extra reps. No endurance benefit.

Search Amazon for l-citrulline →

B

HMB

Nothing for trained lifters. A small gain in older adults.

Search Amazon for hmb supplement →

B

Taurine

A small endurance effect. The longevity claim is animals only.

Search Amazon for taurine supplement →

Testosterone boosters

B

Tongkat ali

Raised testosterone in 5 small trials.

Search Amazon for tongkat ali →

B

Ecdysterone and turkesterone

Trials disagree. Many products contain almost none.

Search Amazon for ecdysterone →

B

Zinc

Fixes a shortfall. Did not raise testosterone in well-fed men.

Search Amazon for zinc supplement →

B

Boron

One 8-man study says yes. The only placebo trial says no.

Search Amazon for boron supplement →

Sleep and stress

A

Melatonin

Proven, and small. About 7 minutes.

Search Amazon for melatonin →

B

Ashwagandha

Small trials. Rare liver injury on record.

Search Amazon for ashwagandha →

B

Glycine

Three small trials. One had 7 men.

Search Amazon for glycine powder →

B

Chamomile

Rated sleep a little better. No extra sleep.

Search Amazon for chamomile supplement →

Longevity

B

Urolithin A

Two trials. Side results up, main results flat.

Search Amazon for urolithin a →

Fat loss and metabolism, other

B

Berberine

Small drops in cholesterol and blood sugar. Mostly short trials from China.

Search Amazon for berberine →

Skin and hair

B

Glutathione

Small skin trials. Drips made people sick in 2026.

Search Amazon for glutathione supplement →

Gut health

A

Psyllium (soluble fiber)

Helped about 1 extra person in 7 with IBS.

Search Amazon for psyllium husk →

B

Peppermint oil

Beat placebo for IBS symptoms, with more side effects.

Search Amazon for peppermint oil capsules →

B

Probiotics

Some strains help. Which one matters.

Search Amazon for probiotics →

B

Glutamine

One striking IBS trial. Pooled data show no clear change.

Search Amazon for l-glutamine →

B

Zinc carnosine

Tiny studies on gut leakiness. No stomach-lining trial.

Search Amazon for zinc carnosine →

B

Digestive enzymes

Less bloating after one very fatty meal, in 18 people.

Search Amazon for digestive enzymes →

Keep going

We show what studies found. We never tell you what to take. Supplements can clash with medicines. Check with a doctor or pharmacist first.