Melanotan II
Darkened skin in 2 of 3 men in one tiny study. Never approved.
Grade B: Some human proof
Small, early or mixed results in people.
The grade is for the use people talk about, not for every use. Filed under: Skin and hair.
How it works
A lab-made copy of the hormone that tells skin to make pigment. It also hits receptors tied to appetite and erections.
How it was given in studies
Injection under the skin, in a pilot study of 3 men.
This is what the studies did. It is not a how-to. Source: Pilot study in 3 men. Life Sciences, 1996.
What studies saw
A 1996 pilot study gave it to 3 men for two weeks. Two got darker skin. They also had nausea, and on-and-off erections for 1 to 5 hours after a dose.
The trade-off
It was never approved. FDA points to published case reports of serious harm in users, including melanoma and priapism, an erection that will not go down.
When it showed up, in studies
Darker skin in 2 of 3 men in one tiny study.
Sources
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Keep going
We show what studies found. We never tell you what to take. Doses vary by study. Check the sources and talk to a doctor.