MK-677
A pill, not a peptide. Raised appetite and blood sugar in trials.
Grade B: Some human proof
Small, early or mixed results in people.
The grade is for the use people talk about, not for every use. Filed under: Growth hormone boosters.
How it works
A pill that mimics ghrelin and raises growth hormone and IGF-1.
How it was given in studies
By mouth. It is a pill.
This is what the studies did. It is not a how-to. Source: Two-year trial in older adults. Annals of Internal Medicine, 2008.
What studies saw
IGF-1 rose within weeks. A two-year trial added about 1.1 kg of lean mass with no gain in strength.
The trade-off
Raised blood sugar and appetite. A hip-fracture trial stopped early over heart failure cases in people taking it.
When it showed up, in studies
IGF-1 and appetite rise within weeks. So does blood sugar.
About 1.1 kg of lean mass over two years, with no strength gain.
Sources
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Keep going
We show what studies found. We never tell you what to take. Doses vary by study. Check the sources and talk to a doctor.