Semaglutide
FDA-approved. Prescription only.
Grade A: Strong human proof
Big trials in people, and it worked.
The grade is for the use people talk about, not for every use. Filed under: Fat loss (GLP-1 family).
How it works
Copies GLP-1, a gut hormone that tells your brain you are full and slows your stomach.
How it was given in studies
Injection under the skin, in the big weight-loss trials. The FDA label also covers a tablet taken by mouth.
This is what the studies did. It is not a how-to. Source: Trial follow-up. Diabetes, Obesity and Metabolism, 2022; FDA label on DailyMed.
What studies saw
About 15% of body weight lost over 68 weeks, against 2% on placebo.
The trade-off
Nausea is common. Weight tends to come back after stopping.
When it showed up, in studies
Appetite drops in the first weeks.
About 15% of body weight over 68 weeks.
Sources
Put this grade on your site
Copy the line below. The badge links back to this page, so readers can check the sources. It grades the compound in studies. It does not rate any product or seller.
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Keep going
We show what studies found. We never tell you what to take. Doses vary by study. Check the sources and talk to a doctor.